Turns out, aggressive breast cancers return to a flexible, earlier state found in fetal breast tissue. This cellular reprogramming may be the key to cancer's ability to form new cell types, evolve drug resistance and metastasize to other locations in the body.
A team of researchers at the Salk Institute has identified a master switch that appears to control the dynamic behavior of tumor cells that makes some aggressive cancers difficult to treat.
The gene Sox10 directly
Previous studies have found that the eyes of people who had died from Alzheimer's showed signs of thinning in the center of the retina and deterioration of the optic nerve. In this new study, Apte's team used a noninvasive technique called optical coherence tomography angiography to examine the thickness of the retinas and fibers in the optic nerves of 30 people, average age mid-70s, who had no symptoms of Alzheimer's. A form of the test is available at many eye doctors in th
Novartis’s efforts to tackle an elusive gene mutation behind tough-to-treat breast cancer were rewarded on Thursday, as the Swiss drugmaker said one of its investigational medicines slowed disease progression. nalysts said the drug, called BYL719, is on a trajectory to take a leading role in advanced breast cancer treatment. Novartis said its drug combined with hormone therapy improved progression-free survival in breast cancer patients whose tumors had hormone receptors but
It's been notoriously difficult to develop medicines for Alzheimer's disease, the sixth leading cause of death in the United States. Each year, it seems, pharmaceutical companies release data from studies of promising drug candidates that merit only a collective sigh of disappointment. In search of fresh ideas, researchers have begun to borrow a phrase or two from the more familiar language of cancer treatment. Some scientists are studying precision medicine, or personalized
Recent studies show more women in the U.S. are living with metastatic breast cancer, or breast cancer that has spread. And many are living longer thanks in part to new treatments being tested to try to beat the disease.
Morgan Mitchell and her fiance hit the gym five days a week. Morgan has four marathons under her belt, works at least 60 hours a week and travels for her job. She's doing all of this.. while battling stage 4 breast cancer. "Yeah I'm 29. And I had no fami
Sleeping pills taken by hundreds of thousands may boost the risk of Alzheimer's, a study suggests. Researchers found the risk of developing the memory-robbing disorder is higher for patients taking benzodiazepines and Z-drugs. And the huge analysis revealed a higher risk for those on stronger medications, and for those who have taken the drugs for longer than recommended. Figures suggest there are at least 260,000 people in Britain and nearly 100 million in the US who take be
Breast cancer is scary, and for many women, it’s not something we really like to think about. However, as one of the most commonly diagnosed cancers in U.S. women (there are more than 3.1 million breast cancer survivors in the U.S. today), it’s important to be aware of the facts and understand that if ever faced with a diagnosis, you’re not going through it alone and you have options. Treatment and care for breast cancer have improved drastically over the years, so work with
America is finally making progress addressing our Alzheimer’s Problem. Particularly inspiring are discoveries of biomarker measures that allow physicians to accurately diagnose the disease early in its course. We’re also making progress in discovering treatments. Just last week, at the Alzheimer’s Association International Conference in Chicago, we learned that lowering blood pressure might reduce the risk of mild cognitive impairment, a condition that can worsen to dementia,
Johns Hopkins researchers report they have demonstrated in mouse tissue grown in the lab that the cell layer surrounding breast milk ducts reaches out to grab stray cancer cells to keep them from spreading through the body. The findings reveal that this cell layer, called the myoepithelium, is not a stationary barrier to cancer invasion, as scientists previously thought, but an active defense against breast cancer metastasis. Results of the scientists' experiments were publis