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Master switch to control aggressive breast cancers identified

Turns out, aggressive breast cancers return to a flexible, earlier state found in fetal breast tissue. This cellular reprogramming may be the key to cancer's ability to form new cell types, evolve drug resistance and metastasize to other locations in the body. A team of researchers at the Salk Institute has identified a master switch that appears to control the dynamic behavior of tumor cells that makes some aggressive cancers difficult to treat. The gene Sox10 directly control the growth and invasion of a significant fraction of hard-to-treat triple-negative breast cancers.

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