Study Reveals a Weakness of Breast Cancer Bone Metastasis

A new study analyzing the cross-talk between bone cells and cancer cells in metastatic breast cancer models may have uncovered a weakness that can be exploited to stop breast cancer from spreading to the bone.

The study, “The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability,” was published in Cancer Cell.

When cancer metastasizes, cancer cells leave the original tumor, migrate through the bloodstream, and take up residence in other organs, often quite far from the primary tumor. Sometimes, these cells grow into metastatic lesions, which can be deadly.

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