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Cryoablation could treat low risk breast cancer

Cryoablation – the destruction of cancer cells through freezing – shows early indications of effectiveness in treating women with low-risk breast cancers, according to the study. Researchers said that over the four years of the study, there has only been one case of cancer recurrence out of 180 patients. “If the positive preliminary findings are maintained as the patients enrolled in the study continue to be monitored, that will serve as a strong indication of the promise of cryotherapy as an alternative treatment for a specific group of breast cancer patients,” said study lead author Dr Kenneth R. Tomkovich, radiologist at Princeton Radiology and director of Breast Imaging and Interventions

EXPERIMENTAL ALZHEIMER'S DISEASE VACCINE TESTED IN MICE CUT DEMENTIA CASES

Researchers at the University of Texas Southwestern Medical Center in Dallas said a new experimental Alzheimer's disease vaccine showed promising results during recent testing in mice and are hopeful the vaccine will make it to human trials. In the animal trials researchers said the experimental vaccine showed it could delay the effects of the degenerative brain disease. The journey from animal tests to human use is long and arduous, and many promising cures do not withstand it. But a senior author of the research published this week in the journal Alzheimer's Research & Therapy told USA Today if the vaccine is proven safe and effective during human trials it could reduce the total number of

Breast cancer recruits cells from bone marrow to boost growth

Researchers have discovered that breast tumors can boost their growth by recruiting stromal cells originally formed in the bone marrow. The study reveals that the recruitment of bone marrow-derived fibroblasts lowers the odds of surviving breast cancer, but suggests that targeting these cells could be an effective way of treating the disease. Within solid tumors, cancer cells are surrounded by other cell types that, though not cancerous themselves, boost tumor growth and metastasis. Breast tumors, for example, contain large numbers of fibroblast cells that promote cancer cell proliferation, inflammation, and the formation of new blood vessels to supply the growing tumor with nutrients and ox

Alzheimer’s Prediction by MRI Better Than Common Tests

While there is currently no cure for Alzheimer’s disease (AD) and few drugs have had clinical efficacy in slowing progression, early detection is still a high priority to help manage the disease appropriately. Now, a new study by investigators at the Mallinckrodt Institute of Radiology within the Washington University School of Medicine in St. Louis (WUSM), has shown that MRI brain scans perform better than common clinical tests at predicting which people will go on to develop Alzheimer’s disease—a disease affecting 5.5 million Americans. Findings from this new study were presented recently at the annual meeting of the Radiological Society of North America (RSNA) through a presentation entit

A Spark Of Good News For Precision Oncology In Breast Cancer

Last June, I almost wrote about a drug called AZD5363. It’s an AKT inhibitor, the sort of chemical we studied to see if it killed cancer cells in the lab, years ago. I was intrigued by an ASCO abstract: in an AstraZeneca-sponsored trial of metastatic triple-negative breast cancer this pill significantly extended patients’ overall survival from 12.6 to 19.1 months, vs. placebo, when given with standard paclitaxel chemotherapy. This potentially big finding—that an AKT inhibitor extends survival in patients with metastatic breast cancer—got lost amid news about giving less treatment for early-stage disease. It turns out, results from the LOTUS trial of a similar drug, Genentech’s AKT inhibitor

New Report Offers Road Map to Reduce Alzheimer's Risk

On Tuesday, Alzheimer's & Dementia: The Journal of the Alzheimer's Association, published details on a comprehensive Alzheimer’s disease risk reduction program created by the Alzheimer’s Prevention Clinic (APC) at Weill Cornell Medicine in New York City. The APC focuses on early prevention and tailoring treatments to the individual by using a variety of possible interventions. In the paper, the researchers shared guidelines of a workable method for doctors to personalize Alzheimer’s risk management. Early action is especially important, as recent estimates have found that more than 46 million Americans currently have preclinical Alzheimer’s disease, according to the study investigators. To r

Breast screening linked to 60 per cent lower risk of breast cancer death in first 10 years

Women who take part in breast screening have a significantly greater benefit from treatments than those who are not screened, according to a study of more than 50,000 women, led in the UK by Queen Mary University of London. The research, using data from Sweden, finds that women who chose to participate in an organised breast cancer screening programme had a 60 per cent lower risk of dying from breast cancer within 10 years after diagnosis, and a 47 per cent lower risk of dying from breast cancer within 20 years after diagnosis. The authors say that this benefit occurs because screening detects cancers at an earlier stage, meaning that they respond much better to treatment. The study was co-a

Artificial intelligence predicts Alzheimer's years before diagnosis

Timely diagnosis of Alzheimer's disease is extremely important, as treatments and interventions are more effective early in the course of the disease. However, early diagnosis has proven to be challenging. Research has linked the disease process to changes in metabolism, as shown by glucose uptake in certain regions of the brain, but these changes can be difficult to recognize. "Differences in the pattern of glucose uptake in the brain are very subtle and diffuse," said study co-author Jae Ho Sohn, M.D., from the Radiology & Biomedical Imaging Department at the University of California in San Francisco (UCSF). "People are good at finding specific biomarkers of disease, but metabolic changes

This State Has the Highest Rate of Breast Cancer in the Country

Breast cancer is the most common cancer in the United States, with more than 268,000 new diagnoses every year, according to the National Cancer Institute. About 95 percent of those diagnosed are women, but men aren’t immune—around 2,550 men will be diagnosed each year. Breast cancer is prevalent all over the country, but not all states are equal. On average, about 125 women per 100,000 are diagnosed with breast cancer each year, but in some states the rates are much higher. The state where you’ll find the highest rate of new cases is New Hampshire, where 144 women per 100,000 were diagnosed annually between 2011 and 2015, according to the CDC. The other states with the highest breast cancer

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