Hopes rise again for a drug to slow Alzheimer’s disease

Hopes are rising again for a drug to alter the course of Alzheimer's disease after decades of failures. An experimental therapy slowed mental decline by 30 percent in patients who got the highest dose in a mid-stage study, and it removed much of the sticky plaque gumming up their brains, the drug's makers said Wednesday. The results have been highly anticipated and have sent the stock of the two companies involved soaring in recent weeks. The drug from Eisai and Biogen did not meet its main goal in a study of 856 participants, so overall, it was considered a flop. But company officials said that 161 people who got the highest dose every two weeks for 18 months did significantly better than 2

New 'Double Hit' Strategy May Provide New, Minimally Toxic Therapies For Breast Cancer

A new research study has identified a potential new target for therapies that could be used in triple-negative breast cancer, while sparing healthy cells. The work published in Nature Communications by a U.S.-China team, led by researchers at Scripps Research in California, shows how a protein called Rad52 might be a new therapeutic target in some types of cancer. Rad52 participates in the repair of a certain type of DNA damage called a double-strand-break. Repairing DNA may seem like a good idea and in healthy cells it is, but in cancer cells, it can actually keep them alive in a damaged state and prevent therapies from working properly. One cancer type that the researchers believe a Rad52-

Researchers Say They May Have Found ‘Big Bang’ in Alzheimer’s Disease

People in midlife may find some gray hair on the outside of their heads while they develop a new fear about what’s inside their skull. One of the biggest worries is developing dementia. Now, a leading dementia expert says his team has discovered a “big bang” of Alzheimer’s disease — the exact point at which a healthy protein becomes toxic but hasn’t yet formed deadly tangles in the brain. A study from the University of Texas Southwestern’s O’Donnell Brain Institute offers a novel insight into the shape-shifting nature of a tau molecule just before it begins sticking to itself to form larger aggregates. To read the full article, click HERE (Credit: Getty Images)

Women who eat more than the recommended 5 portions of fruit and vegetables a day can reduce their ri

Women who eat at least five portions of fruit and vegetables each day can reduce their risk of breast cancer, a study claims. Scientists found women who stick to the official nutrition guidelines have an 11 per cent lower chance of getting the disease. Broccoli, Brussels sprouts, carrots and yellow peppers all produced the strongest effects, researchers claimed. Harvard University researchers analysed data from 182,000 women over 37 years to make the conclusion. To read the full article, click HERE (Shutterstoc/Suncity)

New PET scan for Alzheimer's disease directly measures synaptic loss

Exciting new research from Yale University has revealed a new method that could potentially objectively diagnose if a person is suffering through the early stages of Alzheimer's disease using a non-invasive PET scan. A major roadblock slowing down effective Alzheimer's research is our inability to easily, or clearly, diagnose the disease at its early stages. Several blood tests are being explored that can identify biomarkers signaling the early presence of the disease, but nothing has proved conclusive enough to move into general clinical use. The new Yale University innovation uses PET imaging technology to evaluate cognitive decline by effectively measuring how much synaptic loss or degrad

What Is Triple-Negative Breast Cancer?

BREAST CANCER IS NOT A single disease, but a variety of subtypes that have different features, prognoses and treatments. Based on an analysis of the characteristics of the tumor, breast cancer can be classified into several molecular subtypes. This is important information for your doctor to collect at the time of diagnosis, as it will guide treatment decisions and next steps in your care. More precise diagnoses can lead to better treatment options for patients. "At the time of diagnosis, we take a piece of tissue and stain it [to look] for three markers in the tissue," says Dr. Daniel Stover, a breast medical oncologist, translational scientist and member of the Translational Therapeutics P

Alzheimer's drug trial results 'extremely encouraging'

“Extremely encouraging” results from a trial of a new Alzheimer’s drug sent shares of pharmaceutical company Biogen up nearly 20 percent Friday, CNBCreported. Biogen (NASDAQ:BIIB) and Tokyo-based drugmaker Eisai reported “statistically significant” evidence that the drug, BAN2401, can slow progression of Alzheimer’s, which causes progressive mental deterioration and degeneration of the brain. The drug, developed in collaboration between Eisai and Swedish biotechnology company BioArctic, targets beta amyloid proteins that form plaques in the brain, speculated to be the cause of the disease. Biogen chairman Stelios Papadopoulos told CNBC that BAN2401 is the first drug that seems to have the ab

New approach to breast cancer screening — tailoring guidelines for each patient — may save lives and

Preventive care experts have been divided for years on how to best counsel women on when to get breast cancer screenings. But a new study suggests that women might benefit from individualized approaches to mammograms rather than from universal guidelines. The study, published Thursday in JAMA Oncology, looks at personalized screening protocols tailored to each woman’s risk of developing breast cancer. The study showed that not offering mammograms to women at low risk for breast cancer might reduce the harms associated with screening, while still maintaining the benefits. And it might even be more cost-effective. To read the full article, click HERE (RICH PEDRONCELLI/AP)

Excessive Iron in the Brain May Be a Factor in Alzheimer's Disease

A type of iron called magnetite may lead researchers down the path to a more effective treatment for Alzheimer’s disease. Magnetite is not usually found in the human brain, but researchers say the metal is present in the brains of people affected by Alzheimer’s. The scientists say the magnetite is found in the abnormal protein clusters known as amyloid plaques that are symptomatic of this disease. Understanding why they’re there could lead to more effective treatment. To read the full article, click HERE (Getty Images)

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